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Advanced Demineralized Bone Matrices (DBM), Cellular Bone Allografts, and Bioactive Synthetics for Spine and Orthopedic Surgical Fusion

Regenerative Excellence

Engineered Bone Graft Technologies for Superior Clinical Fusion

Orthofix and IsoTis biologic matrices are precision-engineered to facilitate reliable bony fusion across complex spine, orthopedic, and reconstructive surgical procedures. Designed and processed under rigorous ISO 13485 and FDA quality standards, our comprehensive biologics portfolio integrates cell-preserved allografts, premium fiber and putty Demineralized Bone Matrices (DBMs), and advanced bioactive synthetics. Backed by extensive peer-reviewed clinical research, our regenerative technologies provide international distributors, healthcare systems, and surgical procurement teams with validated osteoconductive, osteoinductive, and osteogenic properties.

Orthofix Biologics — Accell DBM technology and cellular bone matrix allografts

Orthofix Biologics

Featuring proprietary Accell® technology, Orthofix Biologics deliver enhanced surface area and rapid growth factor signaling to accelerate natural bone formation. Designed for optimal handling in open and minimally invasive spinal fusion (TLIF, PLIF, PCF, and PLF).

  • Patented Accell® DBM matrix formulation
  • Preserved cellular bone matrix (Trinity ELITE™ & Trinity EV3™)
  • High osteoinductive potential with consistent handling properties
  • ISO 13485 and AATB certified tissue processing
IsoTis Biologics — Bioactive synthetics and DBM putty solutions

IsoTis Biologics

A globally trusted pioneer in bone graft substitutes, IsoTis delivers a versatile range of bioactive synthetics, DBM putties, gels, and structural grafts engineered for predictable bone remodeling in orthopedic trauma and spinal reconstruction.

  • Silicated calcium phosphate bioactive synthetics
  • Flowable and malleable DBM putty formulations
  • Exceptional graft containment and radiolucent tracking
  • Extensive international clinical evidence across 40+ countries

Global B2B Standards

Why Global Healthcare Procurement Chooses Orthofix

FDA & CE Compliant
Rigorous regulatory compliance fulfilling international medical device standards for worldwide export.
ISO 13485 Certified
State-of-the-art tissue banking and processing facilities in Irvine, CA and Edison, NJ.
Clinical Validation
Supported by 500+ peer-reviewed studies proving superior fusion rates and safety profiles.
Supply Chain Integrity
Robust global logistics network ensuring prompt, temperature-controlled delivery for overseas partners.

Scientific Expertise

Rigorous Quality Assurance & Clinical Evidence

At Orthofix, every biologic graft substitute is developed through multidisciplinary research involving tissue engineers, orthopedic surgeons, and biomaterial scientists. Our in-house research facilities partner with top-tier tissue banks, including MTF Biologics®, to adhere to the strictest donor screening and aseptic processing protocols.

Whether fulfilling large-scale hospital procurement contracts or supplying regional medical equipment distributors, we provide complete lot traceability, sterile packaging, and comprehensive clinical documentation necessary for rapid regulatory clearance in international markets.

Biologic Portfolio Highlights

  • ▪ Demineralized Bone Matrix (DBM): Accell® Putty, Gel, and Fiber Formulations
  • ▪ Cellular Bone Matrix: Trinity ELITE™ & Trinity EV3™ Allografts
  • ▪ Bioactive Synthetics: IsoTis® Silicated Calcium Phosphate Solutions
  • ▪ Structural Graft Solutions: Cancellous Strips, Cubes & Pellets

Partner with a Global Leader in Medical Biologics

Request complete product specifications, OEM catalog data, regulatory documentation, and international distributor pricing directly from our global medical solutions team.

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